DNAstack
Toronto companies partner to provide an integrated platform that runs the complete clinical genetics workflow, from patient intake to diagnostic report, entirely on Canadian infrastructure.
TORONTO, Ontario (May 7, 2026) — DNAstack and PhenoTips today announced an integrated platform that runs clinical genetics workflows, from patient intake and phenotyping to genomic interpretation and diagnostic report, entirely on Canadian infrastructure. At a time when many countries are investing heavily in sovereign digital infrastructure, this provides a single end-to-end Canadian solution for health systems seeking to operationalize genomic medicine.
Genome sequencing offers faster, more accurate diagnoses and lower long-term healthcare costs. In health systems today, the clinical and laboratory workflows typically run in separate, disconnected systems, with patient data moving between them and often crossing borders to reach commercial analysis services on foreign infrastructure. The result is a fragmented workflow that slows diagnosis, increases the risk of errors, and forces health systems to choose between analytical capability and data sovereignty. The integrated platform eliminates that trade-off by running the full workflow and analysis entirely on domestic infrastructure.
The joint platform enables healthcare providers to capture and structure the patient’s clinical picture, including phenotype, family history, and consent, using PhenoTips’ clinical genomics system embedded within their EHR. They order a test directly through the platform, which feeds the structured data into Omics AI for interpretation. Omics AI orchestrates the workflow from raw sequencing data through variant calling, annotation, and phenotype-driven prioritization, drawing on AI-supported insights from local and global networks without moving sensitive data. Upon laboratory sign-off in Omics AI, the structured diagnostic report is immediately available in PhenoTips for the ordering provider to evaluate alongside the patient’s clinical context.
“Most genetics programs don’t run inside a single hospital or a single EHR. They span sites, systems, and teams,” said Orion Buske, Co-Founder and CEO of PhenoTips. “By integrating PhenoTips and Omics AI, we can now provide a single connected workflow from the clinic to the lab and back, with the data staying in Canada the entire time. That means faster diagnoses for patients, and critical domestic infrastructure for Canadian genomic medicine.”
The partnership combines two proven technologies into a single platform. PhenoTips is in daily clinical use in more than 20 health systems across Canada, the UK, and Europe, with over one million patient records under management. Omics AI powers multiple large-scale, collaborative, global precision medicine initiatives including the Aligning Science Across Parkinson’s Collaborative Research Network, Target ALS Data Engine, and HiFi Solves.
The announcement comes as Canada is moving critical industries onto sovereign infrastructure to keep its sensitive data assets, and the AI trained on them, under domestic control. To support this, Ottawa has committed nearly $900 million to sovereign AI compute. Ontario’s PHIPA and provincial digital health program already require Canadian storage for personal health information, and the recently introduced Bill S-5 further mandates interoperability and prohibits data blocking by health information technology vendors.
“Without a Canadian system, health providers would need to rely on infrastructure provided by foreign software and hardware providers,” said Dr. Marc Fiume, Co-Founder and CEO at DNAstack. “That dependency is a strategic vulnerability for genomic data, which exposes not only patients but their relatives across generations.”
The platform is designed for interoperability. It complies with open standards by the Global Alliance for Genomics & Health (GA4GH), whose protocols power many of the world’s most ambitious genomics initiatives. The platform is technology-agnostic, supporting multiple EHRs, sequencing technologies, analysis pipelines, compute environments, and AI models. As these technologies continue to evolve rapidly, this architecture allows health systems to select the best solutions for patients, now and in the future.
About PhenoTips
PhenoTips is a Toronto-founded company behind the leading clinical platform for genomic medicine, used by over 9,000 healthcare providers at 20+ health systems across Canada, the UK, and Europe. Born from a collaboration between SickKids and the University of Toronto, PhenoTips enables health systems to deliver genomic medicine at scale by managing the full clinical genetics workflow, from patient intake through test ordering and result to diagnosis, embedded within electronic health records including Epic and Oracle Health. PhenoTips is co-leading a $5.4-million initiative, backed by Genome Canada, to build AI-assisted genomic test requisition infrastructure across five Canadian health institutions. An entirely Canada-based team, PhenoTips is trusted by SickKids, CHEO, Trillium Health Partners, provincial health authorities in Alberta, BC, and Nova Scotia, and the majority of Genomic Medicine Services in the UK NHS. With more than one million patient records under management, the platform holds SOC 2, HIPAA, GDPR, DSPT, and CE+ certifications. For more information, visit phenotips.com.
About DNAstack
DNAstack is a Canadian company building sovereign, AI-powered infrastructure for genomic data governance and analysis, with ninety percent of its workforce based in Ontario. Its Omics AI platform spans the full genomic data lifecycle, from sequencing through secondary and tertiary analysis, clinical reporting, and federated knowledge sharing. Omics AI runs in production across seven networks on four continents, and has processed more than 1 million samples for over 100 organizations. Co-developed with more than 40 public and private sector partners representing over $50 million in combined investment, Omics AI is built on Canadian-owned intellectual property. DNAstack has been named a 2024 PICCASO Canada Health Privacy Leader, 2023 Life Sciences Ontario Company of the Year, and 2022 World Economic Forum Technology Pioneer. For more information, visit dnastack.com.