DNAstack
June 14, 2026 (Gothenburg, Sweden) — DNAstack today launched tertiary analysis for long-read genomes, powered by Network Intelligence. The platform draws on evidence from a global network of connected collaborators to shorten turnaround times and increase solve rates, without moving sensitive row-level data between them. DNAstack is unveiling the solution at ESHG 2026 in Gothenburg, June 13th to 16th.
The Opportunity
Long-read HiFi sequencing produces the most accurate and complete genome on the market, resolving every class of variation in a single run, from SNVs and indels to structural variants, repeat expansions, segmental duplications, and paralogs, fully phased and with base-level methylation. These complex variants are major drivers of rare and complex genetic disease, but short reads miss them, so they are largely absent from the reference databases that anchor ACMG/AMP classification and are therefore difficult to interpret.
Already the largest network of its kind, HiFi Solves is a global network launched by PacBio, DNAstack, and a growing community of institutions that is on pace to connect more than 10,000 HiFi genomes across 15 countries this year. Tertiary analysis powered by Network Intelligence is a genomic interpretation layer that runs on top of it, exclusively available for members of HiFi Solves.
The Solution
Tertiary Analysis is the new product. It integrates directly with the output of HiFi instruments and runs a best-practice secondary and tertiary analysis pipeline, paired with Network Intelligence, which combines insights from across the network with AI-powered interpretation. From the complete catalog of variation a long-read genome reveals, the system narrows the field to a focused shortlist of candidates, shortening turnaround time. It surfaces the causal variant within that shortlist, raising diagnostic yield. And it does both without sharing sensitive row-level data, preserving each member’s sovereignty.
“We are proud to deliver a software solution that unlocks the value of HiFi sequencing through global collaboration,” said Alex Robertson, Director of Market Development at DNAstack. “The interest from laboratories around the world has been extraordinary, signalling appetite for a new form of collaborative discovery. What excites us most is what this means for patients and families, who can get answers to questions that would otherwise remain unsolved.”
The Impact
Together these capabilities deliver faster turnaround, higher yield, and uncompromised sovereignty. Cases that had once taken years to resolve become solvable in days. Long read sequencing is showing the potential to increase solve rates, relative to existing testing practices, by 10 percent. Because collaborators share aggregative insights instead of copying row level data, they can work together immediately without taking months to negotiate bilateral data sharing agreements.
“The power of this is in the community,” said Marc Fiume, CEO of DNAstack. “Every genome added makes the network stronger, so each member’s hardest case becomes easier to solve because of everyone else’s. No single institution, however large, can learn on its own what the whole field can learn together. This is how we can accelerate closing the gap between sequence and solve.”
Powered by Open Standards
The solution is powered by open standards co-developed with the Global Alliance for Genomics & Health. Its network insights extend a lineage of federated discovery pioneered by the Matchmaker Exchange and the Variant Level Matching community, which let researchers find collaborators investigating the same candidate gene or variant without exposing patient records. HiFi Solves is principled on reciprocity. In order to draw insights from the network, members must also contribute to it, making discovery collaborative by design rather than by exception.
Book a Demo
DNAstack is demonstrating long-read tertiary analysis on Omics AI at ESHG 2026 in Gothenburg, June 13 to 16, at Svenska Mässan. To arrange a briefing, contact Alex Robertson or request a demo at dnastack.com.
About DNAstack
DNAstack is a Canadian company building sovereign, AI-powered infrastructure for genomic data governance and analysis. Its Omics AI platform spans the full genomic data lifecycle, from sequencing through secondary and tertiary analysis, reporting, and federated knowledge sharing. Omics AI runs in production across seven networks on four continents and has processed more than 1 million samples for over 100 organizations. DNAstack has been named a 2024 PICCASO Canada Health Privacy Leader, 2023 Life Sciences Ontario Company of the Year, and 2022 World Economic Forum Technology Pioneer. For more information, visit dnastack.com.
About HiFi Solves
HiFi Solves is a global network of institutions using long-read HiFi sequencing to accelerate the discovery of genomic variation and its impact on human health. By enabling real-time, federated insights across member institutions, HiFi Solves makes responsible, privacy-preserving collaboration the default rather than the exception. PacBio customers are invited to join HiFi Solves and contribute to a global effort to drive faster, more impactful discoveries. Learn more at https://hifisolves.org/join.